P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity.

Journal Article (Journal Article;Review)

Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse models for studying human xenobiotic metabolism. Here, we describe both genetic humanization and human liver chimeric mouse models, focusing on the advantages and limitations while outlining their key features and applications. Although this field of biomedical science is relatively young, these humanized mouse models have the potential to transform preclinical drug testing and eventually lead to a more cost-effective and rapid development of new therapies.

Full Text

Duke Authors

Cited Authors

  • Bissig, K-D; Han, W; Barzi, M; Kovalchuk, N; Ding, L; Fan, X; Pankowicz, FP; Zhang, Q-Y; Ding, X

Published Date

  • November 2018

Published In

Volume / Issue

  • 46 / 11

Start / End Page

  • 1734 - 1744

PubMed ID

  • 30093418

Pubmed Central ID

  • PMC6199624

Electronic International Standard Serial Number (EISSN)

  • 1521-009X

Digital Object Identifier (DOI)

  • 10.1124/dmd.118.083303


  • eng

Conference Location

  • United States