Mitochondrial Impairment in Antibiotic Induced Toxic Optic Neuropathies.

Journal Article (Journal Article;Review)

There is growing evidence for the role of mitochondrial dysfunction in the toxic optic neuropathies. Due to the structural similarities between antibiotic targets and mitochondrial machinery, several antibiotics known to cause optic neuropathy have deleterious effects on mitochondrial function. We review the literature on the prevalence, clinical manifestations, and management of antibiotic induced toxic optic neuropathies. The effect of these antibiotics on mitochondrial function in regard to the optic nerve is discussed.

Full Text

Duke Authors

Cited Authors

  • Yu, JJ; Lee, DH; Gallagher, SP; Kenney, MC; Boisvert, CJ

Published Date

  • October 2018

Published In

Volume / Issue

  • 43 / 10

Start / End Page

  • 1199 - 1204

PubMed ID

  • 30040491

Electronic International Standard Serial Number (EISSN)

  • 1460-2202

Digital Object Identifier (DOI)

  • 10.1080/02713683.2018.1504086


  • eng

Conference Location

  • England