Methionine metabolism in health and cancer: a nexus of diet and precision medicine.

Journal Article (Journal Article;Review)

Methionine uptake and metabolism is involved in a host of cellular functions including methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism, thus coordinating nucleotide and redox status. Each of these functions has been shown in many contexts to be relevant for cancer pathogenesis. Intriguingly, the levels of methionine obtained from the diet can have a large effect on cellular methionine metabolism. This establishes a link between nutrition and tumour cell metabolism that may allow for tumour-specific metabolic vulnerabilities that can be influenced by diet. Recently, a number of studies have begun to investigate the molecular and cellular mechanisms that underlie the interaction between nutrition, methionine metabolism and effects on health and cancer.

Full Text

Duke Authors

Cited Authors

  • Sanderson, SM; Gao, X; Dai, Z; Locasale, JW

Published Date

  • November 2019

Published In

Volume / Issue

  • 19 / 11

Start / End Page

  • 625 - 637

PubMed ID

  • 31515518

Electronic International Standard Serial Number (EISSN)

  • 1474-1768

Digital Object Identifier (DOI)

  • 10.1038/s41568-019-0187-8


  • eng

Conference Location

  • England