Astrocytes in chronic pain and itch.

Journal Article (Journal Article;Review)

Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence suggests that a number of neurological and neuropsychiatric disorders, including chronic pain, may result from astrocyte 'gliopathy'. Indeed, in recent years there has been substantial progress in our understanding of how astrocytes can regulate nociceptive synaptic transmission via neuronal-glial and glial-glial cell interactions, as well as the involvement of spinal and supraspinal astrocytes in the modulation of pain signalling and the maintenance of neuropathic pain. A role of astrocytes in the pathogenesis of chronic itch is also emerging. These developments suggest that targeting the specific pathways that are responsible for astrogliopathy may represent a novel approach to develop therapies for chronic pain and chronic itch.

Full Text

Duke Authors

Cited Authors

  • Ji, R-R; Donnelly, CR; Nedergaard, M

Published Date

  • November 2019

Published In

Volume / Issue

  • 20 / 11

Start / End Page

  • 667 - 685

PubMed ID

  • 31537912

Pubmed Central ID

  • PMC6874831

Electronic International Standard Serial Number (EISSN)

  • 1471-0048

Digital Object Identifier (DOI)

  • 10.1038/s41583-019-0218-1

Language

  • eng

Conference Location

  • England