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Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory.

Publication ,  Journal Article
Liu, Y; Chongsathidkiet, P; Crawford, BM; Odion, R; Dechant, CA; Kemeny, HR; Cui, X; Maccarini, PF; Lascola, CD; Fecci, PE; Vo-Dinh, T
Published in: Immunotherapy
October 2019

Brain tumors present unique therapeutic challenges and they include glioblastoma (GBM) and metastases from cancers of other organs. Current treatment options are limited and include surgical resection, radiation therapy, laser interstitial thermal therapy and chemotherapy. Although much research has been done on the development of immune-based treatment platforms, only limited success has been demonstrated. Herein, we demonstrate a novel treatment of GBM through the use of plasmonic gold nanostars (GNS) as photothermal inducers for synergistic immuno photothermal nanotherapy (SYMPHONY), which combines treatments using gold nanostar and laser-induced photothermal therapy with checkpoint blockade immunotherapy. In the treatment of a murine flank tumor model with the CT-2A glioma cell line, SYMPHONY demonstrated the capability of producing long-term survivors that rejects rechallenge with cancer cells, heralding the successful emergence of immunologic memory. This study is the first to investigate the use of this novel therapy for the treatment of GBM in a murine model.

Duke Scholars

Published In

Immunotherapy

DOI

EISSN

1750-7448

Publication Date

October 2019

Volume

11

Issue

15

Start / End Page

1293 / 1302

Location

England

Related Subject Headings

  • Phototherapy
  • Neoplasms, Experimental
  • Nanotechnology
  • Mice, Inbred C57BL
  • Mice
  • Metal Nanoparticles
  • Laser Therapy
  • Immunotherapy
  • Immunologic Memory
  • Hyperthermia, Induced
 

Citation

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ICMJE
MLA
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Liu, Y., Chongsathidkiet, P., Crawford, B. M., Odion, R., Dechant, C. A., Kemeny, H. R., … Vo-Dinh, T. (2019). Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory. Immunotherapy, 11(15), 1293–1302. https://doi.org/10.2217/imt-2019-0023
Liu, Yang, Pakawat Chongsathidkiet, Bridget M. Crawford, Ren Odion, Cosette A. Dechant, Hanna R. Kemeny, Xiuyu Cui, et al. “Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory.Immunotherapy 11, no. 15 (October 2019): 1293–1302. https://doi.org/10.2217/imt-2019-0023.
Liu Y, Chongsathidkiet P, Crawford BM, Odion R, Dechant CA, Kemeny HR, et al. Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory. Immunotherapy. 2019 Oct;11(15):1293–302.
Liu, Yang, et al. “Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory.Immunotherapy, vol. 11, no. 15, Oct. 2019, pp. 1293–302. Pubmed, doi:10.2217/imt-2019-0023.
Liu Y, Chongsathidkiet P, Crawford BM, Odion R, Dechant CA, Kemeny HR, Cui X, Maccarini PF, Lascola CD, Fecci PE, Vo-Dinh T. Plasmonic gold nanostar-mediated photothermal immunotherapy for brain tumor ablation and immunologic memory. Immunotherapy. 2019 Oct;11(15):1293–1302.
Journal cover image

Published In

Immunotherapy

DOI

EISSN

1750-7448

Publication Date

October 2019

Volume

11

Issue

15

Start / End Page

1293 / 1302

Location

England

Related Subject Headings

  • Phototherapy
  • Neoplasms, Experimental
  • Nanotechnology
  • Mice, Inbred C57BL
  • Mice
  • Metal Nanoparticles
  • Laser Therapy
  • Immunotherapy
  • Immunologic Memory
  • Hyperthermia, Induced