Role of Paracrine Mechanisms

Book Section

Many studies have demonstrated that the exogenous delivery of stem cells into injured myocardium results in functional improvements. It was originally thought that the regenerative properties of these stem cells arose from engraftment into the myocardium and subsequent differentiation into cardiac cells. However, this process was found to occur very rarely; far too low to account for the functional benefits observed. In the past decade, a new paradigm has emerged, namely that stem cells exert their reparative and regenerative effects predominantly through the release of biologically active molecules acting in a paracrine fashion on resident cells.

Full Text

Duke Authors

Cited Authors

  • Hodgkinson, CP; Gomez, JA; Bareja, A; Dzau, VJ

Published Date

  • January 1, 2015

Book Title

  • Stem Cell and Gene Therapy for Cardiovascular Disease

Start / End Page

  • 39 - 48

International Standard Book Number 13 (ISBN-13)

  • 9780128018880

Digital Object Identifier (DOI)

  • 10.1016/B978-0-12-801888-0.00004-7

Citation Source

  • Scopus