Impact of infection on transplantation tolerance.

Journal Article (Journal Article;Review)

Allograft tolerance is the ultimate goal of organ transplantation. Current strategies for tolerance induction mainly focus on inhibiting alloreactive T cells while promoting regulatory immune cells. Pathogenic infections may have direct impact on both effector and regulatory cell populations, therefore can alter host susceptibility to transplantation tolerance induction as well as impair the quality and stability of tolerance once induced. In this review, we will discuss existing data demonstrating the effect of infections on transplantation tolerance, with particular emphasis on the role of the stage of infection (acute, chronic, or latent) and the stage of tolerance (induction or maintenance) in this infection-tolerance interaction. While the deleterious effect of acute infection on tolerance is mainly driven by proinflammatory cytokines induced shortly after the infection, chronic infection may generate exhausted T cells that could in fact facilitate transplantation tolerance. In addition to pathogenic infections, commensal intestinal microbiota also has numerous significant immunomodulatory effects that can shape the host alloimmunity following transplantation. A comprehensive understanding of these mechanisms is crucial for the development of therapeutic strategies for robustly inducing and stably maintaining transplantation tolerance while preserving host anti-pathogen immunity in clinically relevant scenarios.

Full Text

Duke Authors

Cited Authors

  • Yu, S; Su, C; Luo, X

Published Date

  • November 2019

Published In

Volume / Issue

  • 292 / 1

Start / End Page

  • 243 - 263

PubMed ID

  • 31538351

Pubmed Central ID

  • 31538351

Electronic International Standard Serial Number (EISSN)

  • 1600-065X

Digital Object Identifier (DOI)

  • 10.1111/imr.12803

Language

  • eng

Conference Location

  • England