Chronic Kidney Disease and Coronary Artery Disease: JACC State-of-the-Art Review.

Journal Article (Journal Article;Review)

Chronic kidney disease (CKD) is a major risk factor for coronary artery disease (CAD). As well as their high prevalence of traditional CAD risk factors, such as diabetes and hypertension, persons with CKD are also exposed to other nontraditional, uremia-related cardiovascular disease risk factors, including inflammation, oxidative stress, and abnormal calcium-phosphorus metabolism. CKD and end-stage kidney disease not only increase the risk of CAD, but they also modify its clinical presentation and cardinal symptoms. Management of CAD is complicated in CKD patients, due to their likelihood of comorbid conditions and potential for side effects during interventions. This summary of the Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference on CAD and CKD (including end-stage kidney disease and transplant recipients) seeks to improve understanding of the epidemiology, pathophysiology, diagnosis, and treatment of CAD in CKD and to identify knowledge gaps, areas of controversy, and priorities for research.

Full Text

Duke Authors

Cited Authors

  • Sarnak, MJ; Amann, K; Bangalore, S; Cavalcante, JL; Charytan, DM; Craig, JC; Gill, JS; Hlatky, MA; Jardine, AG; Landmesser, U; Newby, LK; Herzog, CA; Cheung, M; Wheeler, DC; Winkelmayer, WC; Marwick, TH; Conference Participants,

Published Date

  • October 8, 2019

Published In

Volume / Issue

  • 74 / 14

Start / End Page

  • 1823 - 1838

PubMed ID

  • 31582143

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2019.08.1017


  • eng

Conference Location

  • United States