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Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.

Publication ,  Journal Article
Iglesias, AI; Ong, JS; Khawaja, AP; Gharahkhani, P; Tedja, MS; Verhoeven, VJM; Bonnemaijer, PWM; Wolfs, RCW; Young, TL; Jansonius, NM ...
Published in: Invest Ophthalmol Vis Sci
July 1, 2019

PURPOSE: To determine genetic correlations between common myopia and primary open-angle glaucoma (POAG). METHODS: We tested the association of myopia polygenic risk scores (PRSs) with POAG and POAG endophenotypes using two studies: the Australian & New Zealand Registry of Advanced Glaucoma (ANZRAG) study comprising 798 POAG cases with 1992 controls, and the Rotterdam Study (RS), a population-based study with 11,097 participants, in which intraocular pressure (IOP) and optic disc parameter measurements were catalogued. PRSs were derived from genome-wide association study meta-analyses conducted by the Consortium for Refractive Error and Myopia (CREAM) and 23andMe. In total, 12 PRSs were constructed and tested. Further, we explored the genetic correlation between myopia, POAG, and POAG endophenotypes by using the linkage disequilibrium score regression (LDSC) method. RESULTS: We did not find significant evidence for an association between PRS of myopia with POAG (P = 0.81), IOP (P = 0.07), vertical cup-disc ratio (P = 0.42), or cup area (P = 0.25). We observed a nominal association with retinal nerve fiber layer (P = 7.7 × 10-3) and a significant association between PRS for myopia and disc area (P = 1.59 × 10-9). Using the LDSC method, we found a genetic correlation only between myopia and disc area (genetic correlation [RhoG] = -0.12, P = 1.8 × 10-3), supporting the findings of the PRS approach. CONCLUSIONS: Using two complementary approaches we found no evidence to support a genetic overlap between myopia and POAG; our results suggest that the comorbidity of these diseases is not influenced by common variants. The association between myopia and optic disc size is well known and validates this methodology.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2019

Volume

60

Issue

8

Start / End Page

3142 / 3149

Location

United States

Related Subject Headings

  • Risk Factors
  • Registries
  • Refraction, Ocular
  • Prospective Studies
  • Optic Disk
  • Ophthalmology & Optometry
  • New Zealand
  • Myopia
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Iglesias, A. I., Ong, J. S., Khawaja, A. P., Gharahkhani, P., Tedja, M. S., Verhoeven, V. J. M., … International Glaucoma Genetics Consortium (IGGC) and Consortium for Refractive Error and Myopia (CREAM), . (2019). Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci, 60(8), 3142–3149. https://doi.org/10.1167/iovs.18-26231
Iglesias, Adriana I., Jue Sheng Ong, Anthony P. Khawaja, Puya Gharahkhani, Milly S. Tedja, Virginie J. M. Verhoeven, Pieter W. M. Bonnemaijer, et al. “Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.Invest Ophthalmol Vis Sci 60, no. 8 (July 1, 2019): 3142–49. https://doi.org/10.1167/iovs.18-26231.
Iglesias AI, Ong JS, Khawaja AP, Gharahkhani P, Tedja MS, Verhoeven VJM, et al. Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3142–9.
Iglesias, Adriana I., et al. “Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.Invest Ophthalmol Vis Sci, vol. 60, no. 8, July 2019, pp. 3142–49. Pubmed, doi:10.1167/iovs.18-26231.
Iglesias AI, Ong JS, Khawaja AP, Gharahkhani P, Tedja MS, Verhoeven VJM, Bonnemaijer PWM, Wolfs RCW, Young TL, Jansonius NM, Craig JE, Stambolian D, van Duijn CM, MacGregor S, Klaver CCW, International Glaucoma Genetics Consortium (IGGC) and Consortium for Refractive Error and Myopia (CREAM). Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3142–3149.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 1, 2019

Volume

60

Issue

8

Start / End Page

3142 / 3149

Location

United States

Related Subject Headings

  • Risk Factors
  • Registries
  • Refraction, Ocular
  • Prospective Studies
  • Optic Disk
  • Ophthalmology & Optometry
  • New Zealand
  • Myopia
  • Middle Aged
  • Male