Predictors of Radiographic Osteoarthritis 2 to 3 Years After Anterior Cruciate Ligament Reconstruction: Data From the MOON On-site Nested Cohort.

Journal Article (Journal Article)

Background

Multiple studies have shown that patients are susceptible to posttraumatic osteoarthritis (PTOA) after an anterior cruciate ligament (ACL) injury, even with ACL reconstruction (ACLR). Prospective studies using multivariable analysis to identify risk factors for PTOA are lacking.

Purpose/hypothesis

This study aimed to identify baseline predictors of radiographic PTOA after ACLR at an early time point. We hypothesized that meniscal injuries and cartilage lesions would be associated with worse radiographic PTOA using the Osteoarthritis Research Society International (OARSI) atlas criteria.

Study design

Cohort study; Level of evidence, 3.

Methods

A total of 421 patients who underwent ACLR returned on-site for standardized posteroanterior semiflexed knee radiography at a minimum of 2 years after surgery. The mean age was 19.8 years, with 51.3% female patients. At baseline, data on demographics, graft type, meniscal status/treatment, and cartilage status were collected. OARSI atlas criteria were used to grade all knee radiographs. Multivariable ordinal regression models identified baseline predictors of radiographic OARSI grades at follow-up.

Results

Older age (odds ratio [OR], 1.06) and higher body mass index (OR, 1.05) were statistically significantly associated with a higher OARSI grade in the medial compartment. Patients who underwent meniscal repair and partial meniscectomy had statistically significantly higher OARSI grades in the medial compartment (meniscal repair OR, 1.92; meniscectomy OR, 2.11) and in the lateral compartment (meniscal repair OR, 1.96; meniscectomy OR, 2.97). Graft type, cartilage lesions, sex, and Marx activity rating scale score had no significant association with the OARSI grade.

Conclusion

Older patients with a higher body mass index who have an ACL tear with a concurrent meniscal tear requiring partial meniscectomy or meniscal repair should be advised of their increased risk of developing radiographic PTOA. Alternatively, patients with an ACL tear with an articular cartilage lesion can be reassured that they are not at an increased risk of developing early radiographic knee PTOA at 2 to 3 years after ACLR.

Full Text

Duke Authors

Cited Authors

  • MOON Knee Group, ; Jones, MH; Oak, SR; Andrish, JT; Brophy, RH; Cox, CL; Dunn, WR; Flanigan, DC; Fleming, BC; Huston, LJ; Kaeding, CC; Kolosky, M; Kuyumcu, G; Lynch, TS; Magnussen, RA; Matava, MJ; Parker, RD; Reinke, EK; Scaramuzza, EA; Smith, MV; Winalski, C; Wright, RW; Zajichek, A; Spindler, KP

Published Date

  • August 30, 2019

Published In

Volume / Issue

  • 7 / 8

Start / End Page

  • 2325967119867085 -

PubMed ID

  • 31516911

Pubmed Central ID

  • PMC6719483

Electronic International Standard Serial Number (EISSN)

  • 2325-9671

International Standard Serial Number (ISSN)

  • 2325-9671

Digital Object Identifier (DOI)

  • 10.1177/2325967119867085

Language

  • eng