A valid and reliable measure of constipation-related quality of life.

Published

Journal Article

PURPOSE: Few existing measures assess constipation-specific quality of life. This study sought to develop a valid and reliable quality-of-life measure for constipation. METHODS: First, we created a preliminary instrument that assessed quality-of-life domains affected by constipation: body image, eating, mood, and relationships with others. We conducted focus groups both with patients with constipation seeking treatment and the health care providers who treat them. Next, a 59-item questionnaire was given to 240 subjects with constipation (83% female) and 103 healthy volunteers (63% female). Test-retest reliability and discriminant, convergent, and divergent validity were assessed. RESULTS: Exploratory factor analysis revealed four domains: Social Impairment (five items), Distress (six items), Eating Habits (three items), and Bathroom Attitudes (four items). Internal consistency and test-retest reliability for all subscales was high (Cronbach's alpha = 0.89; intraclass correlation coefficient = 0.87). All domains discriminated well between subjects with constipation and healthy volunteers (P < 0.001). Convergent validity was excellent: all subscales correlated highly with the Irritable Bowel Syndrome Quality of Life Scale total score (P < 0.001) and the Medical Outcomes Study Short Form-36 physical component and mental component summary scores (P < 0.001). Scores from our Constipation-Related Quality of Life measure were not significantly correlated with the Social Desirability Scale, demonstrating divergent validity. CONCLUSIONS: Our findings support the reliability and validity of the Constipation-Related Quality of Life measure. Future validation of the Constipation-Related Quality of Life measure for assessing changes in quality of life in response to treatments for constipation is needed.

Full Text

Duke Authors

Cited Authors

  • Wang, JY; Hart, SL; Lee, J; Berian, JR; McCrea, GL; Varma, MG

Published Date

  • August 2009

Published In

Volume / Issue

  • 52 / 8

Start / End Page

  • 1434 - 1442

PubMed ID

  • 19617757

Pubmed Central ID

  • 19617757

Electronic International Standard Serial Number (EISSN)

  • 1530-0358

Digital Object Identifier (DOI)

  • 10.1007/DCR.0b013e3181a51196

Language

  • eng

Conference Location

  • United States