The expanded role of fatty acid metabolism in cancer: new aspects and targets.


Journal Article (Review)

Cancer cells undergo metabolic reprogramming to support cell proliferation, growth, and dissemination. Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise one well-documented aspect of this reprogramming. Recent studies have revealed an expanded range of roles played by FA in promoting the aggressiveness of cancer while simultaneously identifying new potential targets for cancer therapy. This article provides a brief review of these advances in our understanding of FA metabolism in cancer, highlighting both recent discoveries and the inherent challenges caused by the metabolic plasticity of cancer cells in targeting lipid metabolism for cancer therapy.

Full Text

Duke Authors

Cited Authors

  • Chen, M; Huang, J

Published Date

  • September 2019

Published In

  • Precis Clin Med

Volume / Issue

  • 2 / 3

Start / End Page

  • 183 - 191

PubMed ID

  • 31598388

Pubmed Central ID

  • 31598388

Electronic International Standard Serial Number (EISSN)

  • 2516-1571

Digital Object Identifier (DOI)

  • 10.1093/pcmedi/pbz017


  • eng

Conference Location

  • England