Can laboratory model systems instruct human limb regeneration?

Journal Article (Journal Article)

Regeneration has fascinated scientists since well before the 20th century revolutions in genetics and molecular biology. The field of regenerative biology has grown steadily over the past decade, incorporating advances in imaging, genomics and genome editing to identify key cell types and molecules involved across many model organisms. Yet for many or most tissues, it can be difficult to predict when and how findings from these studies will advance regenerative medicine. Establishing technologies to stimulate regrowth of a lost or amputated limb with a patterned replicate, as salamanders do routinely, is one of the most challenging directives of tissue regeneration research. Here, we speculate upon what research avenues the field must explore to move closer to this capstone achievement.

Full Text

Duke Authors

Cited Authors

  • Cox, BD; Yun, MH; Poss, KD

Published Date

  • October 2, 2019

Published In

Volume / Issue

  • 146 / 20

PubMed ID

  • 31578190

Pubmed Central ID

  • PMC6917474

Electronic International Standard Serial Number (EISSN)

  • 1477-9129

Digital Object Identifier (DOI)

  • 10.1242/dev.181016


  • eng

Conference Location

  • England