Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.

Journal Article (Journal Article)

Recent studies have shown that global translational reprogramming is an early activation event in pattern-triggered immunity, when plants recognize microbe-associated molecular patterns. However, it is not fully known whether translational regulation also occurs in subsequent immune responses, such as effector-triggered immunity (ETI). In this study, we performed genome-wide ribosome profiling in Arabidopsis upon RPS2-mediated ETI activation and discovered that specific groups of genes were translationally regulated, mostly in coordination with transcription. These genes encode enzymes involved in aromatic amino acid, phenylpropanoid, camalexin, and sphingolipid metabolism. The functional significance of these components in ETI was confirmed by genetic and biochemical analyses. Our findings provide new insights into diverse translational regulation of plant immune responses and demonstrate that translational coordination of metabolic gene expression is an important strategy for ETI.

Full Text

Duke Authors

Cited Authors

  • Yoo, H; Greene, GH; Yuan, M; Xu, G; Burton, D; Liu, L; Marqués, J; Dong, X

Published Date

  • January 2020

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 88 - 98

PubMed ID

  • 31568832

Pubmed Central ID

  • PMC6946852

Electronic International Standard Serial Number (EISSN)

  • 1752-9867

International Standard Serial Number (ISSN)

  • 1674-2052

Digital Object Identifier (DOI)

  • 10.1016/j.molp.2019.09.009


  • eng