Tamoxifen Improves Glucose Tolerance in a Delivery-, Sex-, and Strain-Dependent Manner in Mice.

Journal Article (Journal Article)

Tamoxifen, a selective estrogen-receptor modulator, is widely used in mouse models to temporally control gene expression but is also known to affect body composition. We report that tamoxifen has significant and sustained effects on glucose tolerance, independent of effects on insulin sensitivity, in mice. IP, but not oral, tamoxifen delivery improved glucose tolerance in three inbred mouse strains. The extent and persistence of tamoxifen-induced effects were sex and strain dependent. These findings highlight the need to revise commonly used tamoxifen-based protocols for gene manipulation in mice by including longer chase periods after injection, oral delivery, and the use of tamoxifen-treated littermate controls.

Full Text

Duke Authors

Cited Authors

  • Ceasrine, AM; Ruiz-Otero, N; Lin, EE; Lumelsky, DN; Boehm, ED; Kuruvilla, R

Published Date

  • April 2019

Published In

Volume / Issue

  • 160 / 4

Start / End Page

  • 782 - 790

PubMed ID

  • 30759201

Pubmed Central ID

  • PMC6424092

Electronic International Standard Serial Number (EISSN)

  • 1945-7170

International Standard Serial Number (ISSN)

  • 0013-7227

Digital Object Identifier (DOI)

  • 10.1210/en.2018-00985


  • eng