Mitochondrial Dysfunction in Cardiac Surgery.

Journal Article (Review;Journal Article)

Mitochondria are key to the cellular response to energetic demand, but are also vital to reactive oxygen species signaling, calcium hemostasis, and regulation of cell death. Cardiac surgical patients with diabetes, heart failure, advanced age, or cardiomyopathies may have underlying mitochondrial dysfunction or be more sensitive to perioperative mitochondrial injury. Mitochondrial dysfunction, due to ischemia/reperfusion injury and an increased systemic inflammatory response due to exposure to cardiopulmonary bypass and surgical tissue trauma, impacts myocardial contractility and predisposes to arrhythmias. Strategies for perioperative mitochondrial protection and recovery include both well-established cardioprotective protocols and targeted therapies that remain under investigation.

Full Text

Duke Authors

Cited Authors

  • Cherry, AD

Published Date

  • December 2019

Published In

Volume / Issue

  • 37 / 4

Start / End Page

  • 769 - 785

PubMed ID

  • 31677690

Pubmed Central ID

  • PMC6986803

International Standard Serial Number (ISSN)

  • 1932-2275

Digital Object Identifier (DOI)

  • 10.1016/j.anclin.2019.08.003


  • eng