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Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?

Publication ,  Journal Article
Morrison, M; Hughes, HY; Naggie, S; Syn, W-K
Published in: Dig Dis Sci
December 2019

PURPOSE OF REVIEW: Liver disease is a leading cause of non-AIDS-related death in the HIV population since the introduction of highly active antiretroviral treatment (HAART). Recent studies suggest that patients with HIV are at high risk for nonalcoholic fatty liver disease (NAFLD) and progressive liver fibrosis. Evidence for the prevalence, risk factors, and diagnostic methodologies of NAFLD in patients with HIV mono-infection is summarized here. RECENT FINDINGS: Although limited, published studies suggest that the prevalence of NAFLD is higher (30-50%) and progresses at an increased rate in patients with HIV compared to the general population. Identifying those at risk for significant liver fibrosis is critical, preferably with non-invasive screening tests. While there is a paucity of evidence in this population, transient elastography (TE) appears to provide a sensitive, non-invasive screening modality. Identifying NAFLD early will allow for dietary and lifestyle interventions, as well as future drug therapies to decrease the risk of progressive liver fibrosis and cirrhosis in the high-risk HIV population. Clinicians should be aware of this risk and consider using TE for NAFLD diagnosis and surveillance.

Duke Scholars

Published In

Dig Dis Sci

DOI

EISSN

1573-2568

Publication Date

December 2019

Volume

64

Issue

12

Start / End Page

3394 / 3401

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk
  • Prevalence
  • Non-alcoholic Fatty Liver Disease
  • Liver Neoplasms
  • Liver Function Tests
  • Liver Cirrhosis
  • Liver
  • Humans
  • HIV Infections
 

Citation

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Chicago
ICMJE
MLA
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Morrison, M., Hughes, H. Y., Naggie, S., & Syn, W.-K. (2019). Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern? Dig Dis Sci, 64(12), 3394–3401. https://doi.org/10.1007/s10620-019-05861-7
Morrison, Margaret, Heather Y. Hughes, Susanna Naggie, and Wing-Kin Syn. “Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?Dig Dis Sci 64, no. 12 (December 2019): 3394–3401. https://doi.org/10.1007/s10620-019-05861-7.
Morrison M, Hughes HY, Naggie S, Syn W-K. Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern? Dig Dis Sci. 2019 Dec;64(12):3394–401.
Morrison, Margaret, et al. “Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?Dig Dis Sci, vol. 64, no. 12, Dec. 2019, pp. 3394–401. Pubmed, doi:10.1007/s10620-019-05861-7.
Morrison M, Hughes HY, Naggie S, Syn W-K. Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern? Dig Dis Sci. 2019 Dec;64(12):3394–3401.
Journal cover image

Published In

Dig Dis Sci

DOI

EISSN

1573-2568

Publication Date

December 2019

Volume

64

Issue

12

Start / End Page

3394 / 3401

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk
  • Prevalence
  • Non-alcoholic Fatty Liver Disease
  • Liver Neoplasms
  • Liver Function Tests
  • Liver Cirrhosis
  • Liver
  • Humans
  • HIV Infections