Outcomes of high-risk acute promyelocytic leukemia patients treated with arsenic trioxide (ATO)/all trans retinoic acid (ATRA) based induction and consolidation without maintenance phase: A case Series.

Published online

Journal Article

Patients with high-risk acute promyelocytic leukemia (APL) have inferior outcomes compared with patients with low-risk APL, predominantly due to higher risk of early mortality related to hemorrhage. The majority of regimens contain prolonged maintenance, but the impact of this phase is not clear in the era of all trans retinoic acid (ATRA) and arsenic trioxide (ATO). We present a retrospective analysis of 10 patients that were treated for high risk APL based on the consolidation treatment phase of APL 0406 study without subsequent maintenance. With a median follow up of 38 months, all patients remain in remission.

Full Text

Duke Authors

Cited Authors

  • Shah, G; Mikhail, FM; Bachiasvili, K; Vachhani, P; Erba, HP; Papadantonakis, N

Published Date

  • October 14, 2019

Published In

PubMed ID

  • 31629725

Pubmed Central ID

  • 31629725

International Standard Serial Number (ISSN)

  • 1658-3876

Digital Object Identifier (DOI)

  • 10.1016/j.hemonc.2019.08.006

Language

  • eng

Conference Location

  • England