Outcomes of high-risk acute promyelocytic leukemia patients treated with arsenic trioxide (ATO)/all trans retinoic acid (ATRA) based induction and consolidation without maintenance phase: A case Series.

Journal Article (Journal Article)

Patients with high-risk acute promyelocytic leukemia (APL) have inferior outcomes compared with patients with low-risk APL, predominantly due to higher risk of early mortality related to hemorrhage. The majority of regimens contain prolonged maintenance, but the impact of this phase is not clear in the era of all trans retinoic acid (ATRA) and arsenic trioxide (ATO). We present a retrospective analysis of 10 patients that were treated for high risk APL based on the consolidation treatment phase of APL 0406 study without subsequent maintenance. With a median follow up of 38 months, all patients remain in remission.

Full Text

Duke Authors

Cited Authors

  • Shah, G; Mikhail, FM; Bachiasvili, K; Vachhani, P; Erba, HP; Papadantonakis, N

Published Date

  • September 2020

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 143 - 146

PubMed ID

  • 31629725

Electronic International Standard Serial Number (EISSN)

  • 2589-0646

Digital Object Identifier (DOI)

  • 10.1016/j.hemonc.2019.08.006


  • eng

Conference Location

  • Saudi Arabia