Programming DNA-Based Biomolecular Reaction Networks on Cancer Cell Membranes.

Journal Article (Journal Article)

DNA is a highly programmable biomolecule and has been used to construct biological circuits for different purposes. An important development of DNA circuits is to process the information on receptors on cell membranes. In this Communication, we introduce an architecture to program localized DNA-based biomolecular reaction networks on cancer cell membranes. Based on our architecture, various types of reaction networks have been experimentally demonstrated, from simple linear cascades to reaction networks of complex structures. These localized DNA-based reaction networks can be used for medical applications such as cancer cell detection. Compared to prior work on DNA circuits for evaluating cell membrane receptors, the DNA circuits made by our architecture have several major advantages including simpler design, lower leak, lower cost, and higher signal-to-background ratio.

Full Text

Duke Authors

Cited Authors

  • Song, T; Shah, S; Bui, H; Garg, S; Eshra, A; Fu, D; Yang, M; Mokhtar, R; Reif, J

Published Date

  • October 2019

Published In

Volume / Issue

  • 141 / 42

Start / End Page

  • 16539 - 16543

PubMed ID

  • 31600065

Electronic International Standard Serial Number (EISSN)

  • 1520-5126

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/jacs.9b05598


  • eng