Molecular Biology and Evolution of Cancer: From Discovery to Action.

Journal Article (Journal Article)

Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.

Full Text

Duke Authors

Cited Authors

  • Somarelli, JA; Gardner, H; Cannataro, VL; Gunady, EF; Boddy, AM; Johnson, NA; Fisk, JN; Gaffney, SG; Chuang, JH; Li, S; Ciccarelli, FD; Panchenko, AR; Megquier, K; Kumar, S; Dornburg, A; DeGregori, J; Townsend, JP

Published Date

  • February 1, 2020

Published In

Volume / Issue

  • 37 / 2

Start / End Page

  • 320 - 326

PubMed ID

  • 31642480

Pubmed Central ID

  • PMC6993850

Electronic International Standard Serial Number (EISSN)

  • 1537-1719

Digital Object Identifier (DOI)

  • 10.1093/molbev/msz242

Language

  • eng

Conference Location

  • United States