Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

Published online

Journal Article

How neurons develop their morphology is an important question in neurobiology. Here we describe a new pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 kinase (TAOK2), also known as TAO2, is essential for dendrite morphogenesis. TAOK2 downregulation impairs basal dendrite formation in vivo without affecting apical dendrites. Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAOK2 overexpression restores dendrite formation in cultured cortical neurons from Nrp1(Sema-) mice, which express Nrp1 receptors incapable of binding Sema3A. TAOK2 overexpression also ameliorates the basal dendrite impairment resulting from Nrp1 downregulation in vivo. Finally, Sema3A and TAOK2 modulate the formation of basal dendrites through the activation of the c-Jun N-terminal kinase (JNK). These results delineate a pathway whereby Sema3A and Nrp1 transduce signals through TAOK2 and JNK to regulate basal dendrite development in cortical neurons.

Full Text

Duke Authors

Cited Authors

  • de Anda, FC; Rosario, AL; Durak, O; Tran, T; Gräff, J; Meletis, K; Rei, D; Soda, T; Madabhushi, R; Ginty, DD; Kolodkin, AL; Tsai, L-H

Published Date

  • June 10, 2012

Published In

Volume / Issue

  • 15 / 7

Start / End Page

  • 1022 - 1031

PubMed ID

  • 22683681

Pubmed Central ID

  • 22683681

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.3141

Language

  • eng

Conference Location

  • United States