IMAGE: high-powered detection of genetic effects on DNA methylation using integrated methylation QTL mapping and allele-specific analysis.
Identifying genetic variants that are associated with methylation variation-an analysis commonly referred to as methylation quantitative trait locus (mQTL) mapping-is important for understanding the epigenetic mechanisms underlying genotype-trait associations. Here, we develop a statistical method, IMAGE, for mQTL mapping in sequencing-based methylation studies. IMAGE properly accounts for the count nature of bisulfite sequencing data and incorporates allele-specific methylation patterns from heterozygous individuals to enable more powerful mQTL discovery. We compare IMAGE with existing approaches through extensive simulation. We also apply IMAGE to analyze two bisulfite sequencing studies, in which IMAGE identifies more mQTL than existing approaches.
Duke Scholars
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Related Subject Headings
- Wolves
- Quantitative Trait Loci
- Papio
- Genomics
- DNA Methylation
- Chromosome Mapping
- Bioinformatics
- Animals
- 08 Information and Computing Sciences
- 06 Biological Sciences
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Wolves
- Quantitative Trait Loci
- Papio
- Genomics
- DNA Methylation
- Chromosome Mapping
- Bioinformatics
- Animals
- 08 Information and Computing Sciences
- 06 Biological Sciences