Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from Daphne odora.

Journal Article (Journal Article)

Three novel gnidimacrin related macrocyclic daphnanes (GMDs), daphneodorins A-C (2-4), were isolated from Daphne odora Thunb., together with gnidimacrin (1). Their structures were established by extensive physicochemical and spectroscopic analyses. Compounds 2 and 3 potently inhibited HIV-1 replication at subnanomolar concentrations (EC50 0.16 and 0.25 nM, respectively). Compounds 2-4 represent a novel type of GMDs that are highly oxygenated on the macrocyclic ring, suggesting good potential for anti-HIV drug development by further chemical modification.

Full Text

Duke Authors

Cited Authors

  • Otsuki, K; Li, W; Asada, Y; Chen, C-H; Lee, K-H; Koike, K

Published Date

  • January 3, 2020

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 11 - 15

PubMed ID

  • 31680527

Pubmed Central ID

  • PMC7437546

Electronic International Standard Serial Number (EISSN)

  • 1523-7052

Digital Object Identifier (DOI)

  • 10.1021/acs.orglett.9b03539


  • eng

Conference Location

  • United States