Rapid Brain Nicotine Uptake from Electronic Cigarettes.

Journal Article (Journal Article)

This study sought to determine brain nicotine kinetics from use of the increasingly popular electronic cigarette (E-cig). Methods: In 17 E-cig users (9 men and 8 women), brain uptake of nicotine after inhalation from E-cigs was directly assessed using 11C-nicotine PET. The brain nicotine kinetics were compared with those from smoking combustible cigarettes (C-cigs). Results: A single puff of E-cig vapor caused the nicotine concentration in the brain to rise quickly (mean time to reach 50% of maximum brain nicotine concentration, 27 s), with a peak amplitude 25% higher in women than men, resembling previous observations with C-cigs. Nonetheless, the accumulation from E-cigs (24%) was less than that from C-cigs (32%) in both men and women. Conclusion: E-cigs can deliver nicotine to the brain with a rapidity similar to that of C-cigs. Therefore, to the extent that rapid brain uptake promotes smoking reward, E-cigs might maintain a degree of nicotine dependence and also serve as a noncombustible substitute for cigarettes.

Full Text

Duke Authors

Cited Authors

  • Solingapuram Sai, KK; Zuo, Y; Rose, JE; Garg, PK; Garg, S; Nazih, R; Mintz, A; Mukhin, AG

Published Date

  • June 2020

Published In

Volume / Issue

  • 61 / 6

Start / End Page

  • 928 - 930

PubMed ID

  • 31676729

Pubmed Central ID

  • PMC8008769

Electronic International Standard Serial Number (EISSN)

  • 1535-5667

Digital Object Identifier (DOI)

  • 10.2967/jnumed.119.230748


  • eng

Conference Location

  • United States