The Potential Utility of Aripiprazole Augmentation for Major Depressive Disorder with Mixed Features Specifier: A Retrospective Study.


Journal Article

Objective: The present study aimed to observe potential benefit of aripiprazole augmentation in the treatment of major depressive disorder with mixed specifier (MDDM) in naturalistic treatment setting. Methods: Data were collected from MDDM patients using a retrospective chart review for 8 weeks (week -8 and week 0) in routine practice. All patients were on current antidepressants upon starting of aripiprazole. Patients were treated without restriction of doses of aripiprazole. The primary endpoint was the mean change of Montgomery-Åsberg Depression Rating Scale (MADRS) total scores along with various secondary endpoint measures. Results: In total 38 patients were analyzed. The changes of MADRS, Clinical Global Impression (CGI)-severity, Young Mania Rating Scale, Sheehan Disability Scale, and CGI-clinical benefit total scores from baseline to the endpoint were -7.1, -0.8, -4.9, -4.1, and -3.6, respectively (all p < 0.0001). At the endpoint, the responder and remitter rates by MADRS score criteria were approximately 32% and 21%, respectively. Conclusion: The present findings have clearly shown the effectiveness and tolerability of aripiprazole augmentation for MDDM patients in routine practice. The present study warrants subsequent, adequately-powered, well-controlled studies for generalizability near future.

Full Text

Duke Authors

Cited Authors

  • Han, C; Wang, S-M; Bahk, W-M; Lee, S-J; Patkar, AA; Masand, PS; Pae, C-U

Published Date

  • November 20, 2019

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 495 - 502

PubMed ID

  • 31671486

Pubmed Central ID

  • 31671486

International Standard Serial Number (ISSN)

  • 1738-1088

Digital Object Identifier (DOI)

  • 10.9758/cpn.2019.17.4.495


  • eng

Conference Location

  • Korea (South)