Associations between PM2.5 and risk of preterm birth among liveborn infants.


Journal Article

PURPOSE:Studies suggest exposure to ambient particulate matter less than 2.5 μg/m3 in aerodynamic diameter (PM2.5) may be associated with preterm birth (PTB), but few have evaluated how this is modified by ambient temperature. We investigated the relationship between PM2.5 exposure during pregnancy and PTB in infants without birth defects (1999-2006) and enrolled in the National Birth Defects Prevention Study and how it is modified by concurrent temperature. METHODS:PTB was defined as spontaneous or iatrogenic delivery before 37 weeks. Exposure was assigned using inverse distance weighting with up to four monitors within 50 kilometers of maternal residence. To account for state-level variations, a Bayesian two-level hierarchal model was developed. RESULTS:PTB was associated with PM2.5 during the third and fourth months of pregnancy (range: (odds ratio (95% confidence interval) = 1.00 (0.35, 2.15) to 1.49 (0.82, 2.68) and 1.31 (0.56, 2.91) to 1.62 (0.7, 3.32), respectively); no week of exposure conveyed greater risk. Temperature may modify this relationship; higher local average temperatures during pregnancy yielded stronger positive relationships between PM2.5 and PTB compared to nonstratified results. CONCLUSIONS:Results add to literature on associations between PM2.5 and PTB, underscoring the importance of considering co-exposures when estimating effects of PM2.5 exposure during pregnancy.

Full Text

Duke Authors

Cited Authors

  • Alman, BL; Stingone, JA; Yazdy, M; Botto, LD; Desrosiers, TA; Pruitt, S; Herring, AH; Langlois, PH; Nembhard, WN; Shaw, GM; Olshan, AF; Luben, TJ; National Birth Defects Prevention Study,

Published Date

  • November 2019

Published In

Volume / Issue

  • 39 /

Start / End Page

  • 46 - 53.e2

PubMed ID

  • 31678056

Pubmed Central ID

  • 31678056

Electronic International Standard Serial Number (EISSN)

  • 1873-2585

International Standard Serial Number (ISSN)

  • 1047-2797

Digital Object Identifier (DOI)

  • 10.1016/j.annepidem.2019.09.008


  • eng