Corneal crosslinking: Current protocols and clinical approach.

Journal Article (Journal Article;Review)

Members of the ASCRS Cornea Clinical Committee performed a review of the current literature on the corneal crosslinking (CXL) procedure for treating corneal ectasia. The members explored the data on the techniques currently in use and under investigation, including their advantages, safety profiles, risks, and cost analyses, compared with data on corneal transplantation. They concluded that CXL limits the progression of keratoconus, thus reducing the need for transplantation. They also found that compared with permitting the disease to progress naturally, CXL techniques carry significant and long-term cost and safety benefits, primarily by reducing the need for corneal transplantation. Studies of various CXL techniques (eg, epithelium-on treatment, changes in ultraviolet light parameters, riboflavin composition) continue with the ultimate goal of improving the procedure's safety and efficacy.

Full Text

Duke Authors

Cited Authors

  • Beckman, KA; Gupta, PK; Farid, M; Berdahl, JP; Yeu, E; Ayres, B; Chan, CC; Gomes, JAP; Holland, EJ; Kim, T; Starr, CE; Mah, FS; ASCRS Cornea Clinical Committee,

Published Date

  • November 2019

Published In

Volume / Issue

  • 45 / 11

Start / End Page

  • 1670 - 1679

PubMed ID

  • 31706520

Electronic International Standard Serial Number (EISSN)

  • 1873-4502

Digital Object Identifier (DOI)

  • 10.1016/j.jcrs.2019.06.027


  • eng

Conference Location

  • United States