Activity-Dependent Transcription Collaborates with Local Dendritic Translation to Encode Stimulus-Specificity in the Genome Binding of NPAS4.

Journal Article (Journal Article)

A new study in Cell (Brigidi et al., 2019) shows that local dendritic versus somatic translation of the neuronal activity-inducible transcription factor NPAS4 drives the formation of distinct heterodimers that enable stimulus-specificity to be encoded into the pattern of NPAS4 binding across the genome.

Full Text

Duke Authors

Cited Authors

  • West, AE

Published Date

  • November 20, 2019

Published In

Volume / Issue

  • 104 / 4

Start / End Page

  • 634 - 636

PubMed ID

  • 31751544

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2019.10.022


  • eng

Conference Location

  • United States