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Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project.

Publication ,  Journal Article
Goode, AP; Schwartz, TA; Kraus, VB; Huebner, JL; George, SZ; Cleveland, RJ; Gracely, R; Jimenez, M; DeFrate, LE; Chen, J; Golightly, YM; Jordan, JM
Published in: J Orthop Res
May 2020

The purpose of this work is to determine the relationship between biomarkers of inflammation, structure, and pain with radiographic disc space narrowing (DSN) in community-based participants. A total of 74 participants (37 cases and 37 controls) enrolled in the Johnston County Osteoarthritis Project during 2006-2010 were selected. The cases had at least mild radiographic DSN and low back pain (LBP). The controls had neither radiographic evidence of DSN nor LBP. The measured analytes from human serum included N-cadherin, Keratin-19, Lumican, CXCL6, RANTES, IL-17, IL-6, BDNF, OPG, and NPY. A standard dolorimeter measured pressure-pain threshold. The coefficients of variation were used to evaluate inter- and intra-assay reliability. Participants with similar biomarker profiles were grouped together using cluster analysis. The binomial regression models were used to estimate risk ratios (RR) and 95% confidence intervals (CI) in propensity score-matched models. Significant associations were found between radiographic DSN and OPG (RR = 3.90; 95% CI: 1.83, 8.31), IL-6 (RR = 2.54; 95% CI: 1.92, 3.36), and NPY (RR = 2.06 95% CI: 1.62, 2.63). Relative to a cluster with low levels of biomarkers, a cluster representing elevated levels of OPG, RANTES, Lumican, Keratin-19, and NPY (RR = 3.04; 95% CI: 1.22, 7.54) and a cluster representing elevated levels of NPY (RR = 2.91; 95% CI: 1.15, 7.39) were significantly associated with radiographic DSN. Clinical Significance: These findings suggest that individual and combinations of biochemical biomarkers may reflect radiographic DSN. This is just one step toward understanding the relationships between biochemical biomarkers and DSN that may lead to improved intervention delivery. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:1027-1037, 2020.

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Published In

J Orthop Res

DOI

EISSN

1554-527X

Publication Date

May 2020

Volume

38

Issue

5

Start / End Page

1027 / 1037

Location

United States

Related Subject Headings

  • Osteoarthritis, Spine
  • Orthopedics
  • Middle Aged
  • Male
  • Low Back Pain
  • Intervertebral Disc Degeneration
  • Humans
  • Female
  • Case-Control Studies
  • Biomarkers
 

Citation

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Goode, A. P., Schwartz, T. A., Kraus, V. B., Huebner, J. L., George, S. Z., Cleveland, R. J., … Jordan, J. M. (2020). Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project. J Orthop Res, 38(5), 1027–1037. https://doi.org/10.1002/jor.24534
Goode, Adam P., Todd A. Schwartz, Virginia B. Kraus, Janet L. Huebner, Steven Z. George, Rebecca J. Cleveland, Richard Gracely, et al. “Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project.J Orthop Res 38, no. 5 (May 2020): 1027–37. https://doi.org/10.1002/jor.24534.
Goode AP, Schwartz TA, Kraus VB, Huebner JL, George SZ, Cleveland RJ, et al. Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project. J Orthop Res. 2020 May;38(5):1027–37.
Goode, Adam P., et al. “Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project.J Orthop Res, vol. 38, no. 5, May 2020, pp. 1027–37. Pubmed, doi:10.1002/jor.24534.
Goode AP, Schwartz TA, Kraus VB, Huebner JL, George SZ, Cleveland RJ, Gracely R, Jimenez M, DeFrate LE, Chen J, Golightly YM, Jordan JM. Inflammatory, Structural, and Pain Biochemical Biomarkers May Reflect Radiographic Disc Space Narrowing: The Johnston County Osteoarthritis Project. J Orthop Res. 2020 May;38(5):1027–1037.
Journal cover image

Published In

J Orthop Res

DOI

EISSN

1554-527X

Publication Date

May 2020

Volume

38

Issue

5

Start / End Page

1027 / 1037

Location

United States

Related Subject Headings

  • Osteoarthritis, Spine
  • Orthopedics
  • Middle Aged
  • Male
  • Low Back Pain
  • Intervertebral Disc Degeneration
  • Humans
  • Female
  • Case-Control Studies
  • Biomarkers