Overcoming a travel burden to high-volume centers for treatment of retroperitoneal sarcomas is associated with improved survival.

Journal Article

BACKGROUND: Guidelines recommend treatment of retroperitoneal sarcomas (RPS) at high-volume centers. However, high-volume centers may not be accessible locally. This national study compared outcomes of RPS resection between local low-volume centers and more distant high-volume centers. METHODS: Patients treated for RPS were identified from the National Cancer Database (1998-2012). Travel distance and annual hospital volume were divided into quartiles. Two groups were identified: (1) short travel to low-volume hospitals (ST/LV), (2) long travel to high-volume hospitals (LT/HV). Outcomes were adjusted for clinical, tumor, and treatment characteristics. RESULTS: Two thousand five hundred ninety-nine patients met the inclusion criteria. The LT/HV cohort was younger and more often white (p < 0.01). The LT/HV group had more comorbidities, higher tumor grade, and more often radical resections and radiotherapy (all p < 0.05). The ST/LV group underwent significantly more R2 resections (4.4% vs. 2.6%, p = 0.003). Thirty-day mortality was significantly lower in the LT/HV group (1.2% vs. 2.8%, p = 0.0026). Five-year survival was better among the LT/HV group (63% vs. 53%, p < 0.0001). After adjustment, the LT/HV group had a 27% improvement in overall survival (HR 0.73, p = 0.0009). CONCLUSIONS: This national study suggests that traveling to high-volume centers for the treatment of RPS confers a significant short-term and long-term survival advantage, supporting centralized care for RPS.

Full Text

Duke Authors

Cited Authors

  • Schmitz, R; Adam, MA; Blazer, DG

Published Date

  • November 4, 2019

Published In

Volume / Issue

  • 17 / 1

Start / End Page

  • 180 -

PubMed ID

  • 31684956

Pubmed Central ID

  • 31684956

Electronic International Standard Serial Number (EISSN)

  • 1477-7819

Digital Object Identifier (DOI)

  • 10.1186/s12957-019-1728-z

Language

  • eng

Conference Location

  • England