Connect MM Registry as a national reference for United States multiple myeloma patients.

Journal Article (Journal Article)

BACKGROUND: The Surveillance, Epidemiology, and End Results (SEER) database and National Cancer Database (NCDB) show improved overall survival (OS) in patients with multiple myeloma (MM) over the last 15 years. This analysis evaluated the validity of the largely community-based Connect MM Registry as a national reference for MM. METHODS: Baseline disease characteristics and survival in US newly diagnosed MM patients were examined using the Connect MM Registry as well as SEER and NCDB databases. Baseline characteristics predictive of longer survival in Connect MM were also identified. RESULTS: As of February 2017, 3011 patients were enrolled in the Connect MM Registry; 2912 were treated. Median age at time of MM diagnosis and age range were numerically similar from 2010 to 2015 across all 3 registries; SEER had a higher representation of nonwhite racial groups than that in the other 2 registries. OS rates suggest proportionate improvement with year of diagnosis among the 3 registries. A Cox proportional hazards model suggests that younger age (<65 years) is associated with longer survival (vs ≥75; HR, 0.39; 95% confidence interval, 0.34-0.46) in the Connect MM Registry. However, sex (HR, 0.91; P = .15) and race (black vs white; HR, 0.88; P = .21) were not associated with longer OS. CONCLUSIONS: Data from the Connect MM Registry appear to be largely representative of national trends, comprehensive, and reliable representations of the national MM population. Baseline characteristics were comparable, and survival similarly improved over time among the 3 registries. CLINICALTRIALS. GOV, IDENTIFIER: NCT01081028.

Full Text

Duke Authors

Cited Authors

  • Ailawadhi, S; Jagannath, S; Narang, M; Rifkin, RM; Terebelo, HR; Toomey, K; Durie, BGM; Hardin, JW; Gasparetto, CJ; Wagner, L; Omel, JL; Kumar, V; Yue, L; Kitali, A; Agarwal, A; Abonour, R; Connect MM Registry Investigators,

Published Date

  • January 2020

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 35 - 42

PubMed ID

  • 31701679

Pubmed Central ID

  • PMC6943143

Electronic International Standard Serial Number (EISSN)

  • 2045-7634

Digital Object Identifier (DOI)

  • 10.1002/cam4.2656


  • eng

Conference Location

  • United States