Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.
Journal Article (Journal Article)
In recent years, there has been increasing interest in the role of lymphatics in organ repair and regeneration, due to their importance in immune surveillance and fluid homeostasis. Experimental approaches aimed at boosting lymphangiogenesis following myocardial infarction in mice, were shown to promote healing of the heart. Yet, the mechanisms governing cardiac lymphatic growth remain unclear. Here, we identify two distinct lymphatic populations in the hearts of zebrafish and mouse, one that forms through sprouting lymphangiogenesis, and the other by coalescence of isolated lymphatic cells. By tracing the development of each subset, we reveal diverse cellular origins and differential response to signaling cues. Finally, we show that lymphatic vessels are required for cardiac regeneration in zebrafish as mutants lacking lymphatics display severely impaired regeneration capabilities. Overall, our results provide novel insight into the mechanisms underlying lymphatic formation during development and regeneration, opening new avenues for interventions targeting specific lymphatic populations.
Full Text
Duke Authors
Cited Authors
- Gancz, D; Raftrey, BC; Perlmoter, G; Marín-Juez, R; Semo, J; Matsuoka, RL; Karra, R; Raviv, H; Moshe, N; Addadi, Y; Golani, O; Poss, KD; Red-Horse, K; Stainier, DY; Yaniv, K
Published Date
- November 8, 2019
Published In
Volume / Issue
- 8 /
PubMed ID
- 31702554
Pubmed Central ID
- PMC6881115
Electronic International Standard Serial Number (EISSN)
- 2050-084X
Digital Object Identifier (DOI)
- 10.7554/eLife.44153
Language
- eng
Conference Location
- England