Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Published online

Journal Article

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9. The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.

Full Text

Duke Authors

Cited Authors

  • Noordam, R; Bos, MM; Wang, H; Winkler, TW; Bentley, AR; Kilpeläinen, TO; de Vries, PS; Sung, YJ; Schwander, K; Cade, BE; Manning, A; Aschard, H; Brown, MR; Chen, H; Franceschini, N; Musani, SK; Richard, M; Vojinovic, D; Aslibekyan, S; Bartz, TM; de Las Fuentes, L; Feitosa, M; Horimoto, AR; Ilkov, M; Kho, M; Kraja, A; Li, C; Lim, E; Liu, Y; Mook-Kanamori, DO; Rankinen, T; Tajuddin, SM; van der Spek, A; Wang, Z; Marten, J; Laville, V; Alver, M; Evangelou, E; Graff, ME; He, M; Kühnel, B; Lyytikäinen, L-P; Marques-Vidal, P; Nolte, IM; Palmer, ND; Rauramaa, R; Shu, X-O; Snieder, H; Weiss, S; Wen, W; Yanek, LR; Adolfo, C; Ballantyne, C; Bielak, L; Biermasz, NR; Boerwinkle, E; Dimou, N; Eiriksdottir, G; Gao, C; Gharib, SA; Gottlieb, DJ; Haba-Rubio, J; Harris, TB; Heikkinen, S; Heinzer, R; Hixson, JE; Homuth, G; Ikram, MA; Komulainen, P; Krieger, JE; Lee, J; Liu, J; Lohman, KK; Luik, AI; Mägi, R; Martin, LW; Meitinger, T; Metspalu, A; Milaneschi, Y; Nalls, MA; O'Connell, J; Peters, A; Peyser, P; Raitakari, OT; Reiner, AP; Rensen, PCN; Rice, TK; Rich, SS; Roenneberg, T; Rotter, JI; Schreiner, PJ; Shikany, J; Sidney, SS; Sims, M; Sitlani, CM; Sofer, T; Strauch, K; Swertz, MA; Taylor, KD; Uitterlinden, AG; van Duijn, CM; Völzke, H; Waldenberger, M; Wallance, RB; van Dijk, KW; Yu, C; Zonderman, AB; Becker, DM; Elliott, P; Esko, T; Gieger, C; Grabe, HJ; Lakka, TA; Lehtimäki, T; North, KE; Penninx, BWJH; Vollenweider, P; Wagenknecht, LE; Wu, T; Xiang, Y-B; Zheng, W; Arnett, DK; Bouchard, C; Evans, MK; Gudnason, V; Kardia, S; Kelly, TN; Kritchevsky, SB; Loos, RJF; Pereira, AC; Province, M; Psaty, BM; Rotimi, C; Zhu, X; Amin, N; Cupples, LA; Fornage, M; Fox, EF; Guo, X; Gauderman, WJ; Rice, K; Kooperberg, C; Munroe, PB; Liu, C-T; Morrison, AC; Rao, DC; van Heemst, D; Redline, S

Published Date

  • November 12, 2019

Published In

Volume / Issue

  • 10 / 1

Start / End Page

  • 5121 -

PubMed ID

  • 31719535

Pubmed Central ID

  • 31719535

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/s41467-019-12958-0

Language

  • eng

Conference Location

  • England