Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models.

Published online

Journal Article (Review)

Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Additionally, evidence for PRR signaling in non-immune cells and PRR responses to host-derived endogenous ligands has also revealed new pathways controlling the development of CNS autoimmunity. Many PRRs remain uncharacterized in MS and EAE, and understanding the distinct triggers and functions of PRR signaling in CNS autoimmunity requires further investigation. In this brief review, we discuss the diverse pathogenic and protective functions of PRRs in MS and EAE, and highlight major avenues for future research.

Full Text

Duke Authors

Cited Authors

  • Deerhake, ME; Biswas, DD; Barclay, WE; Shinohara, ML

Published Date

  • 2019

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 2644 -

PubMed ID

  • 31781124

Pubmed Central ID

  • 31781124

Electronic International Standard Serial Number (EISSN)

  • 1664-3224

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2019.02644

Language

  • eng

Conference Location

  • Switzerland