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Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration.

Publication ,  Journal Article
Torstrick, FB; Lin, ASP; Safranski, DL; Potter, D; Sulchek, T; Lee, CSD; Gall, K; Guldberg, RE
Published in: Spine
April 2020

An in vivo study examining the functional osseointegration of smooth, rough, and porous surface topographies presenting polyether-ether-ketone (PEEK) or titanium surface chemistry.To investigate the effects of surface topography and surface chemistry on implant osseointegration.Interbody fusion devices have been used for decades to facilitate fusion across the disc space, yet debate continues over their optimal surface topography and chemistry. Though both factors influence osseointegration, the relative effects of each are not fully understood.Smooth, rough, and porous implants presenting either a PEEK or titanium surface chemistry were implanted into the proximal tibial metaphyses of 36 skeletally mature male Sprague Dawley rats. At 8 weeks, animals were euthanized and bone-implant interfaces were subjected to micro-computed tomography analysis (n = 12), histology (n = 4), and biomechanical pullout testing (n = 8) to assess functional osseointegration and implant fixation.Micro-computed tomography analysis demonstrated that bone ingrowth was 38.9 ± 2.8% for porous PEEK and 30.7 ± 3.3% for porous titanium (P = 0.07). No differences in fixation strength were detected between porous PEEK and porous titanium despite titanium surfaces exhibiting an overall increase in bone-implant contact compared with PEEK (P < 0.01). Porous surfaces exhibited increased fixation strength compared with smooth and rough surfaces regardless of surface chemistry (P < 0.05). Across all groups both surface topography and chemistry had a significant overall effect on fixation strength (P < 0.05), but topography accounted for 65.3% of the total variance (ω = 0.65), whereas surface chemistry accounted for 5.9% (ω = 0.06).The effect of surface topography (specifically porosity) dominated the effect of surface chemistry in this study and could lead to further improvements in orthopedic device design. The poor osseointegration of existing smooth PEEK implants may be linked more to their smooth surface topography rather than their material composition.N/A.

Duke Scholars

Published In

Spine

DOI

EISSN

1528-1159

ISSN

0362-2436

Publication Date

April 2020

Volume

45

Issue

8

Start / End Page

E417 / E424

Related Subject Headings

  • X-Ray Microtomography
  • Titanium
  • Surface Properties
  • Rats, Sprague-Dawley
  • Rats
  • Prostheses and Implants
  • Porosity
  • Polymers
  • Polyethylene Glycols
  • Osseointegration
 

Citation

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MLA
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Torstrick, F. B., Lin, A. S. P., Safranski, D. L., Potter, D., Sulchek, T., Lee, C. S. D., … Guldberg, R. E. (2020). Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration. Spine, 45(8), E417–E424. https://doi.org/10.1097/brs.0000000000003303
Torstrick, F Brennan, Angela S. P. Lin, David L. Safranski, Daniel Potter, Todd Sulchek, Christopher S. D. Lee, Ken Gall, and Robert E. Guldberg. “Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration.Spine 45, no. 8 (April 2020): E417–24. https://doi.org/10.1097/brs.0000000000003303.
Torstrick FB, Lin ASP, Safranski DL, Potter D, Sulchek T, Lee CSD, et al. Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration. Spine. 2020 Apr;45(8):E417–24.
Torstrick, F. Brennan, et al. “Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration.Spine, vol. 45, no. 8, Apr. 2020, pp. E417–24. Epmc, doi:10.1097/brs.0000000000003303.
Torstrick FB, Lin ASP, Safranski DL, Potter D, Sulchek T, Lee CSD, Gall K, Guldberg RE. Effects of Surface Topography and Chemistry on Polyether-Ether-Ketone (PEEK) and Titanium Osseointegration. Spine. 2020 Apr;45(8):E417–E424.

Published In

Spine

DOI

EISSN

1528-1159

ISSN

0362-2436

Publication Date

April 2020

Volume

45

Issue

8

Start / End Page

E417 / E424

Related Subject Headings

  • X-Ray Microtomography
  • Titanium
  • Surface Properties
  • Rats, Sprague-Dawley
  • Rats
  • Prostheses and Implants
  • Porosity
  • Polymers
  • Polyethylene Glycols
  • Osseointegration