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Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet?

Publication ,  Journal Article
Emrich, IE; Dederer, J; Kircher, A; Klemis, V; Lennartz, CS; Untersteller, K; Wagenpfeil, S; Fliser, D; Wolf, M; Heine, GH
Published in: Nutr Metab Cardiovasc Dis
December 2019

BACKGROUND AND AIMS: Data of experimental rodent models suggest that hypoxia with subsequent increase in erythropoietin stimulates the expression of the phosphaturic hormone fibroblast growth factor 23 (FGF23). METHODS AND RESULTS: To translate the findings of animal studies into human physiology, herein we exposed eight healthy volunteers to high altitude (2656 m above sea level) for four days. The volunteers were randomized on a low-phosphorous diet (n = 4) or a normal phosphorus diet (n = 4). Although high-altitude exposure caused a significant increase in plasma erythropoietin (EPO) (before high-altitude exposure: low phosphorus: median EPO 6.6 mIU/ml [interquartile range (IQR) 6.0; 8.2], normal phosphorus: median EPO 9.0 mIU/ml [IQR 7.9; 11.5]; at day 2: low phosphorus: median EPO 21.3 mIU/ml [IQR 19.5; 23.8], normal phosphorus: median EPO 19.4 mIU/ml [IQR 18.0; 20.8]), there was no consistent increase in plasma c-terminal FGF23 or plasma intact FGF23. We observed only a single, intermittent peak in c-terminal FGF23 levels after 5 h of maximal aerobic exercise. CONCLUSION: These data do not support a substantial effect of moderate hypoxia alone on the expression of FGF23, but they suggest that combined exercise and high-altitude exposure may temporarily induce FGF23 expression.

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Published In

Nutr Metab Cardiovasc Dis

DOI

EISSN

1590-3729

Publication Date

December 2019

Volume

29

Issue

12

Start / End Page

1361 / 1367

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Time Factors
  • Phosphorus, Dietary
  • Male
  • Humans
  • Healthy Volunteers
  • Germany
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female
 

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Emrich, I. E., Dederer, J., Kircher, A., Klemis, V., Lennartz, C. S., Untersteller, K., … Heine, G. H. (2019). Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet? Nutr Metab Cardiovasc Dis, 29(12), 1361–1367. https://doi.org/10.1016/j.numecd.2019.09.002
Emrich, Insa E., Juliane Dederer, Angelika Kircher, Verena Klemis, Claudia S. Lennartz, Kathrin Untersteller, Stefan Wagenpfeil, Danilo Fliser, Myles Wolf, and Gunnar H. Heine. “Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet?Nutr Metab Cardiovasc Dis 29, no. 12 (December 2019): 1361–67. https://doi.org/10.1016/j.numecd.2019.09.002.
Emrich IE, Dederer J, Kircher A, Klemis V, Lennartz CS, Untersteller K, et al. Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet? Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1361–7.
Emrich, Insa E., et al. “Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet?Nutr Metab Cardiovasc Dis, vol. 29, no. 12, Dec. 2019, pp. 1361–67. Pubmed, doi:10.1016/j.numecd.2019.09.002.
Emrich IE, Dederer J, Kircher A, Klemis V, Lennartz CS, Untersteller K, Wagenpfeil S, Fliser D, Wolf M, Heine GH. Does a rise in plasma erythropoietin after high-altitude exposure affect FGF23 in healthy volunteers on a normal or low-phosphorus diet? Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1361–1367.
Journal cover image

Published In

Nutr Metab Cardiovasc Dis

DOI

EISSN

1590-3729

Publication Date

December 2019

Volume

29

Issue

12

Start / End Page

1361 / 1367

Location

Netherlands

Related Subject Headings

  • Up-Regulation
  • Time Factors
  • Phosphorus, Dietary
  • Male
  • Humans
  • Healthy Volunteers
  • Germany
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female