Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults.

Published

Journal Article

Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results in 100% infection rates. We conducted a double-blind, randomized, dose-escalation study to assess the infectivity of the 7G8 clone of Pf (PfSPZ Challenge [7G8]). Results showed dose-dependent infectivity from 43% for 8 × 102 PfSPZ to 100% for 4.8 × 103 PfSPZ. PfSPZ Challenge (7G8) will allow for more complete assessment by CHMI of antimalarial vaccines and drugs.

Full Text

Cited Authors

  • Laurens, MB; Berry, AA; Travassos, MA; Strauss, K; Adams, M; Shrestha, B; Li, T; Eappen, A; Manoj, A; Abebe, Y; Murshedkar, T; Gunasekera, A; Richie, TL; Lyke, KE; Plowe, CV; Kennedy, JK; Potter, GE; Deye, GA; Sim, BKL; Hoffman, SL

Published Date

  • November 6, 2019

Published In

Volume / Issue

  • 220 / 12

Start / End Page

  • 1962 - 1966

PubMed ID

  • 31419294

Pubmed Central ID

  • 31419294

Electronic International Standard Serial Number (EISSN)

  • 1537-6613

Digital Object Identifier (DOI)

  • 10.1093/infdis/jiz410

Language

  • eng

Conference Location

  • United States