Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults.
Publication
, Journal Article
Laurens, MB; Berry, AA; Travassos, MA; Strauss, K; Adams, M; Shrestha, B; Li, T; Eappen, A; Manoj, A; Abebe, Y; Murshedkar, T; Gunasekera, A ...
Published in: The Journal of infectious diseases
November 2019
Direct venous inoculation of 3.2 × 103 aseptic, purified, cryopreserved, vialed Plasmodium falciparum (Pf) strain NF54 sporozoites, PfSPZ Challenge (NF54), has been used for controlled human malaria infection (CHMI) in the United States, 4 European countries, and 6 African countries. In nonimmune adults, this results in 100% infection rates. We conducted a double-blind, randomized, dose-escalation study to assess the infectivity of the 7G8 clone of Pf (PfSPZ Challenge [7G8]). Results showed dose-dependent infectivity from 43% for 8 × 102 PfSPZ to 100% for 4.8 × 103 PfSPZ. PfSPZ Challenge (7G8) will allow for more complete assessment by CHMI of antimalarial vaccines and drugs.
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Published In
The Journal of infectious diseases
DOI
EISSN
1537-6613
ISSN
0022-1899
Publication Date
November 2019
Volume
220
Issue
12
Start / End Page
1962 / 1966
Related Subject Headings
- Vaccination
- Sporozoites
- Plasmodium falciparum
- Microbiology
- Male
- Malaria, Falciparum
- Malaria Vaccines
- Humans
- Female
- Dose-Response Relationship, Immunologic
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APA
Chicago
ICMJE
MLA
NLM
Laurens, M. B., Berry, A. A., Travassos, M. A., Strauss, K., Adams, M., Shrestha, B., … Hoffman, S. L. (2019). Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults. The Journal of Infectious Diseases, 220(12), 1962–1966. https://doi.org/10.1093/infdis/jiz410
Laurens, Matthew B., Andrea A. Berry, Mark A. Travassos, Kathy Strauss, Matthew Adams, Biraj Shrestha, Tao Li, et al. “Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults.” The Journal of Infectious Diseases 220, no. 12 (November 2019): 1962–66. https://doi.org/10.1093/infdis/jiz410.
Laurens MB, Berry AA, Travassos MA, Strauss K, Adams M, Shrestha B, et al. Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults. The Journal of infectious diseases. 2019 Nov;220(12):1962–6.
Laurens, Matthew B., et al. “Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults.” The Journal of Infectious Diseases, vol. 220, no. 12, Nov. 2019, pp. 1962–66. Epmc, doi:10.1093/infdis/jiz410.
Laurens MB, Berry AA, Travassos MA, Strauss K, Adams M, Shrestha B, Li T, Eappen A, Manoj A, Abebe Y, Murshedkar T, Gunasekera A, Richie TL, Lyke KE, Plowe CV, Kennedy JK, Potter GE, Deye GA, Sim BKL, Hoffman SL. Dose-Dependent Infectivity of Aseptic, Purified, Cryopreserved Plasmodium falciparum 7G8 Sporozoites in Malaria-Naive Adults. The Journal of infectious diseases. 2019 Nov;220(12):1962–1966.
Published In
The Journal of infectious diseases
DOI
EISSN
1537-6613
ISSN
0022-1899
Publication Date
November 2019
Volume
220
Issue
12
Start / End Page
1962 / 1966
Related Subject Headings
- Vaccination
- Sporozoites
- Plasmodium falciparum
- Microbiology
- Male
- Malaria, Falciparum
- Malaria Vaccines
- Humans
- Female
- Dose-Response Relationship, Immunologic