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Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study.

Publication ,  Journal Article
Sjöberg, RL; Wu, WY-Y; Dahlin, AM; Tsavachidis, S; Gliogene Group, ; Bondy, ML; Melin, B
Published in: J Neurooncol
November 2019

BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Preclinical studies suggest that this enzyme may contribute to an environment favorable for growth of malignant glioma. The MAO-A gene is located on the X-chromosome and has at least one functional genetic polymorphism. The aim of the present study was to explore possible effects of MAO-A genotype on development of glioblastoma in males. METHODS: Genotypes for 437 glioma cases and 876 population-based controls from the Swedish Glioma International Case-Control study (GICC) were compared. We analyzed the germline DNA using the Illumina Oncoarray. We selected seven single nucleotide polymorphisms (SNPs) located in the MAO-A gene, and imputed genotypes based on data from the 1000 genomes project. We used 1579 male glioblastoma cases and 1875 controls comprising the whole GICC cohort for subsequent validation of findings. RESULTS: The rs144551722 SNP was a significant predictor of development of glioblastoma in males (p-value = 0.0056) but not in females even after correction for multiple testing. We conducted haplotype analysis to confirm an association between MAO-A gene and risk of glioblastoma (p-value = 0.016). We found similar results in the validation sample. CONCLUSIONS: These results suggest the possibility of a role for the MAO-A enzyme and the MAO-A gene in the development of glioblastoma in males.

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Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

November 2019

Volume

145

Issue

2

Start / End Page

287 / 294

Location

United States

Related Subject Headings

  • Young Adult
  • Sex Characteristics
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Monoamine Oxidase
  • Middle Aged
  • Male
  • Humans
  • Glioblastoma
  • Genotype
 

Citation

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MLA
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Sjöberg, R. L., Wu, W.-Y., Dahlin, A. M., Tsavachidis, S., Gliogene Group, ., Bondy, M. L., & Melin, B. (2019). Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol, 145(2), 287–294. https://doi.org/10.1007/s11060-019-03294-w
Sjöberg, Rickard L., Wendy Yi-Ying Wu, Anna M. Dahlin, Spiridon Tsavachidis, Spiridon Gliogene Group, Melissa L. Bondy, and Beatrice Melin. “Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study.J Neurooncol 145, no. 2 (November 2019): 287–94. https://doi.org/10.1007/s11060-019-03294-w.
Sjöberg RL, Wu WY-Y, Dahlin AM, Tsavachidis S, Gliogene Group, Bondy ML, et al. Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol. 2019 Nov;145(2):287–94.
Sjöberg, Rickard L., et al. “Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study.J Neurooncol, vol. 145, no. 2, Nov. 2019, pp. 287–94. Pubmed, doi:10.1007/s11060-019-03294-w.
Sjöberg RL, Wu WY-Y, Dahlin AM, Tsavachidis S, Gliogene Group, Bondy ML, Melin B. Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol. 2019 Nov;145(2):287–294.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

November 2019

Volume

145

Issue

2

Start / End Page

287 / 294

Location

United States

Related Subject Headings

  • Young Adult
  • Sex Characteristics
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Monoamine Oxidase
  • Middle Aged
  • Male
  • Humans
  • Glioblastoma
  • Genotype