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Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study.

Publication ,  Journal Article
Chen, C; Liu, Y; Cao, Z; Yin, Z; Zhao, F; Lv, Y; Liu, Z; Mao, C; Song, S; Liu, L; Qu, Y; Ji, S; Duan, J; Wang, J; Kraus, VB; Zeng, Y; Shi, X
Published in: Immun Ageing
2019

BACKGROUND: Inflammatory markers, such as high sensitivity C-reactive protein (hs-CRP), and cognitive impairment (CI) are associated with mortality; CRP is related to the deterioration of CI. However, it is still unknown whether these two indices predict mortality independent of each other. Furthermore, their joint effect on all-cause mortality has not been well established, especially in oldest-old adults. METHODS: Based on data from the 2012 wave of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), we included 1447 oldest-old adults (mean age 84.7 years and 58.7% were female, weighted) with information on hs-CRP (stratified by a cutoff value of 3.0 mg/L) and cognition (quantified by Mini-Mental Status Examination (MMSE) scored according to the personal educational level) at baseline. Mortality was assessed in followed 2014 and 2017 waves. Cox proportional hazards regression models were used, with adjustment for hs-CRP and cognition (mutually controlled) and several traditional mortality risk factors. RESULTS: During a median follow-up period of 32.8 months (Q1-Q3, 9.7-59.0 months), 826 participants died. Hs-CRP [HR > 3.0 mg/L vs ≤ 3.0 mg/L: 1.64 (95% CI, 1.17, 2.30)] and cognition [HR CI vs normal: 2.30 (95% CI, 1.64, 3.21)] each was independent predictor of all-cause mortality, even after accounting for each other and other covariates. Monotonic and positive associations were observed in combined analyses, in which the highest mortality risk was obtained in elders with both high hs-CRP> 3.0 mg/L and CI [HR: 3.56 (95% CI, 2.35, 5.38)].The combined effects were stronger in male and younger oldest-old (aged 80-89 years). CONCLUSION: High hs-CRP and CI, both individually and jointly, were associated with increased all-cause mortality risks in Chinese oldest-old. Intervention strategies for preventing inflammation and maintaining adequate cognitive function may be more important in male and younger oldest-old for reducing mortality risk.

Duke Scholars

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Published In

Immun Ageing

DOI

ISSN

1742-4933

Publication Date

2019

Volume

16

Start / End Page

30

Location

England

Related Subject Headings

  • Immunology
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1107 Immunology
  • 1103 Clinical Sciences
 

Citation

APA
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Chen, C., Liu, Y., Cao, Z., Yin, Z., Zhao, F., Lv, Y., … Shi, X. (2019). Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study. Immun Ageing, 16, 30. https://doi.org/10.1186/s12979-019-0170-y
Chen, Chen, Yingchun Liu, Zhaojin Cao, Zhaoxue Yin, Feng Zhao, Yuebin Lv, Zuyun Liu, et al. “Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study.Immun Ageing 16 (2019): 30. https://doi.org/10.1186/s12979-019-0170-y.
Chen C, Liu Y, Cao Z, Yin Z, Zhao F, Lv Y, Liu Z, Mao C, Song S, Liu L, Qu Y, Ji S, Duan J, Wang J, Kraus VB, Zeng Y, Shi X. Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study. Immun Ageing. 2019;16:30.
Journal cover image

Published In

Immun Ageing

DOI

ISSN

1742-4933

Publication Date

2019

Volume

16

Start / End Page

30

Location

England

Related Subject Headings

  • Immunology
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1107 Immunology
  • 1103 Clinical Sciences