Once-daily prolonged-release tacrolimus versus twice-daily tacrolimus in liver transplantation.


Journal Article

OBJECTIVE:For patients who have received a kidney transplant, studies have shown that once-daily prolonged-release tacrolimus (TAC) has similar efficacy and safety to standard twice-daily dosing. The purpose of this study was to perform a meta-analysis to compare the effectiveness and safety of daily TAC (TAC qd) versus standard twice-daily TAC (TAC bid) administration in liver transplantation (LT). DESIGN:Meta-analysis. SETTING AND PARTICIPANTS:We systematically searched the PubMed/MEDLINE, Web of Science, and Cochrane Library databases for studies comparing outcomes of LT patients who received TAC qd versus TAC bid. OUTCOME MEASURES:Results were reported as odds ratios (ORs) with 95% CIs. RESULTS:Six studies, which included 5179 LT recipients (TAC qd = 951; TAC bid = 4228) were included in the analysis. The TAC qd group had a low 1-year graft loss rate (OR 0.70 [95% CI 0.54-0.91], P = 0.008) and lower rate of biopsy-proven acute rejection (BPAR) at 90 days (OR 0.46 [95% CI 0.24-0.89], P = 0.02) compared with the TAC bid group. There was no significant difference in 1-year mortality or the incidence of adverse events after LT between the 2 groups. CONCLUSIONS:Current evidence suggests that TAC qd is safe and effective for LT patients during the first year after transplantation. Longer-term follow-up studies are necessary to determine if TAC qd is safe and effective beyond the first year after LT.

Full Text

Duke Authors

Cited Authors

  • Huang, B; Liu, J; Li, J; Schroder, PM; Chen, M; Deng, R; Deng, S

Published Date

  • November 2019

Published In

Volume / Issue

  • 59 / 6

Start / End Page

  • 816 - 823.e2

PubMed ID

  • 31521585

Pubmed Central ID

  • 31521585

Electronic International Standard Serial Number (EISSN)

  • 1544-3450

International Standard Serial Number (ISSN)

  • 1544-3191

Digital Object Identifier (DOI)

  • 10.1016/j.japh.2019.08.002


  • eng