Histopathological growth patterns and positive margins after resection of colorectal liver metastases.

Journal Article (Journal Article)

BACKGROUND: Histopathological growth patterns (HGPs) of colorectal liver metastases (CRLM) may be an expression of biological tumour behaviour impacting the risk of positive resection margins. The current study aimed to investigate whether the non-desmoplastic growth pattern (non-dHGP) is associated with a higher risk of positive resection margins after resection of CRLM. METHODS: All patients treated surgically for CRLM between January 2000 and March 2015 at the Erasmus MC Cancer Institute and between January 2000 and December 2012 at the Memorial Sloan Kettering Cancer Center were considered for inclusion. RESULTS: Of all patients (n = 1302) included for analysis, 13% (n = 170) had positive resection margins. Factors independently associated with positive resection margins were the non-dHGP (odds ratio (OR): 1.79, 95% confidence interval (CI): 1.11-2.87, p = 0.016) and a greater number of CRLM (OR: 1.15, 95% CI: 1.08-1.23 p < 0.001). Both positive resection margins (HR: 1.41, 95% CI: 1.13-1.76, p = 0.002) and non-dHGP (HR: 1.57, 95% CI: 1.26-1.95, p < 0.001) were independently associated with worse overall survival. CONCLUSION: Patients with non-dHGP are at higher risk of positive resection margins. Despite this association, both positive resection margins and non-dHGP are independent prognostic indicators of worse overall survival.

Full Text

Duke Authors

Cited Authors

  • Nierop, PMH; Höppener, DJ; van der Stok, EP; Galjart, B; Buisman, FE; Balachandran, VP; Jarnagin, WR; Kingham, TP; Allen, PJ; Shia, J; Vermeulen, PB; Groot Koerkamp, B; Grünhagen, DJ; Verhoef, C; D'Angelica, MI

Published Date

  • June 2020

Published In

Volume / Issue

  • 22 / 6

Start / End Page

  • 911 - 919

PubMed ID

  • 31735649

Pubmed Central ID

  • PMC7888172

Electronic International Standard Serial Number (EISSN)

  • 1477-2574

Digital Object Identifier (DOI)

  • 10.1016/j.hpb.2019.10.015


  • eng

Conference Location

  • England