Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.
Published
Journal Article
BACKGROUND: Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, and undertake epidemiologic studies. However, their utility has not extended beyond patients with cancer or recipients of stem cell or solid organ transplants. With newer diagnostic techniques available, it was clear that an update of these definitions was essential. METHODS: To achieve this, 10 working groups looked closely at imaging, laboratory diagnosis, and special populations at risk of IFD. A final version of the manuscript was agreed upon after the groups' findings were presented at a scientific symposium and after a 3-month period for public comment. There were several rounds of discussion before a final version of the manuscript was approved. RESULTS: There is no change in the classifications of "proven," "probable," and "possible" IFD, although the definition of "probable" has been expanded and the scope of the category "possible" has been diminished. The category of proven IFD can apply to any patient, regardless of whether the patient is immunocompromised. The probable and possible categories are proposed for immunocompromised patients only, except for endemic mycoses. CONCLUSIONS: These updated definitions of IFDs should prove applicable in clinical, diagnostic, and epidemiologic research of a broader range of patients at high-risk.
Full Text
Duke Authors
Cited Authors
- Donnelly, JP; Chen, SC; Kauffman, CA; Steinbach, WJ; Baddley, JW; Verweij, PE; Clancy, CJ; Wingard, JR; Lockhart, SR; Groll, AH; Sorrell, TC; Bassetti, M; Akan, H; Alexander, BD; Andes, D; Azoulay, E; Bialek, R; Bradsher, RW; Bretagne, S; Calandra, T; Caliendo, AM; Castagnola, E; Cruciani, M; Cuenca-Estrella, M; Decker, CF; Desai, SR; Fisher, B; Harrison, T; Heussel, CP; Jensen, HE; Kibbler, CC; Kontoyiannis, DP; Kullberg, B-J; Lagrou, K; Lamoth, F; Lehrnbecher, T; Loeffler, J; Lortholary, O; Maertens, J; Marchetti, O; Marr, KA; Masur, H; Meis, JF; Morrisey, CO; Nucci, M; Ostrosky-Zeichner, L; Pagano, L; Patterson, TF; Perfect, JR; Racil, Z; Roilides, E; Ruhnke, M; Prokop, CS; Shoham, S; Slavin, MA; Stevens, DA; Thompson, GR; Vazquez, JA; Viscoli, C; Walsh, TJ; Warris, A; Wheat, LJ; White, PL; Zaoutis, TE; Pappas, PG
Published Date
- September 12, 2020
Published In
- Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Volume / Issue
- 71 / 6
Start / End Page
- 1367 - 1376
PubMed ID
- 31802125
Pubmed Central ID
- 31802125
Electronic International Standard Serial Number (EISSN)
- 1537-6591
Digital Object Identifier (DOI)
- 10.1093/cid/ciz1008
Language
- eng
Conference Location
- United States