Accumulated mutations by 6 months of infection collectively render transmitted/founder HIV-1 significantly less fit.

Journal Article (Journal Article)

OBJECTIVE: Viral fitness plays an important role in HIV-1 evolution, transmission and pathogenesis. However, how mutations accumulated during early infection affect viral fitness has not been well studied. METHODS: Paired infectious molecular clones (IMCs) for transmitted/founder (T/F) and 6-month (6-mo) viruses post infection were generated from 10 infected individuals to investigate the impact of accumulated mutations on viral fitness by comparing 6-mo viruses to their cognate T/F viruses. RESULTS: All ten 6-mo viruses were less fit than their cognate T/F viruses. Moreover, the fitness losses of the 6-mo viruses correlated with the decrease in viral loads from the peak of viremia. CONCLUSION: These results show that the mutations accumulated during half a year post infection collectively reduce viral fitness and thereby contribute to lowering viral loads.

Full Text

Duke Authors

Cited Authors

  • Wang, C; Liu, D; Zuo, T; Hora, B; Cai, F; Ding, H; Kappes, J; Ochsenbauer, C; Kong, W; Yu, X; Bhattacharya, T; Perelson, AS; Gao, F

Published Date

  • February 2020

Published In

Volume / Issue

  • 80 / 2

Start / End Page

  • 210 - 218

PubMed ID

  • 31812703

Pubmed Central ID

  • PMC7010540

Electronic International Standard Serial Number (EISSN)

  • 1532-2742

Digital Object Identifier (DOI)

  • 10.1016/j.jinf.2019.12.001

Language

  • eng

Conference Location

  • England