The Neural Basis for Response Latency in a Sensory-Motor Behavior.

Journal Article (Journal Article)

We seek a neural circuit explanation for sensory-motor reaction times. In the smooth eye movement region of the frontal eye fields (FEFSEM), the latencies of pairs of neurons show trial-by-trial correlations that cause trial-by-trial correlations in neural and behavioral latency. These correlations can account for two-third of the observed variation in behavioral latency. The amplitude of preparatory activity also could contribute, but the responses of many FEFSEM neurons fail to support predictions of the traditional "ramp-to-threshold" model. As a correlate of neural processing that determines reaction time, the local field potential in FEFSEM includes a brief wave in the 5-15-Hz frequency range that precedes pursuit initiation and whose phase is correlated with the latency of pursuit in individual trials. We suggest that the latency of the incoming visual motion signals combines with the state of preparatory activity to determine the latency of the transient response that controls eye movement. IMPACT STATEMENT: The motor cortex for smooth pursuit eye movements contributes to sensory-motor reaction time through the amplitude of preparatory activity and the latency of transient, visually driven responses.

Full Text

Duke Authors

Cited Authors

  • Lee, J; Darlington, TR; Lisberger, SG

Published Date

  • May 14, 2020

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 3055 - 3073

PubMed ID

  • 31828292

Pubmed Central ID

  • PMC7197090

Electronic International Standard Serial Number (EISSN)

  • 1460-2199

Digital Object Identifier (DOI)

  • 10.1093/cercor/bhz294

Language

  • eng

Conference Location

  • United States