Small-molecule nicotinamide for ex vivo expansion of umbilical cord blood.

Journal Article (Journal Article;Review)

Umbilical cord blood transplant is an alternative graft source for patients lacking a human leukocyte antigen-matched donor; however, delayed engraftment times have historically resulted in transplant-related morbidity and mortality from complications such as infections and ineffective hematopoiesis. Recent advances in ex vivo expansion techniques have successfully augmented the initial cell dose delivered from an umbilical cord blood graft, leading to improved immune reconstitution, durable hematopoiesis, decreased transplant-related morbidity and mortality, and better outcomes. Herein we review the data for existing and developing ex vivo expansion techniques, with a focus on the preclinical and clinical data for nicotinamide-mediated cord blood expansion across both malignant and benign hematologic indications.

Full Text

Duke Authors

Cited Authors

  • Islam, P; Horwitz, ME

Published Date

  • December 2019

Published In

Volume / Issue

  • 80 /

Start / End Page

  • 11 - 15

PubMed ID

  • 31786243

Electronic International Standard Serial Number (EISSN)

  • 1873-2399

Digital Object Identifier (DOI)

  • 10.1016/j.exphem.2019.11.006


  • eng

Conference Location

  • Netherlands