Red Blood Cell Deformability, Vasoactive Mediators, and Adhesion.

Published online

Journal Article (Review)

Healthy red blood cells (RBCs) deform readily in response to shear stress in the circulation, facilitating their efficient passage through capillaries. RBCs also export vasoactive mediators in response to deformation and other physiological and pathological stimuli. Deoxygenation of RBC hemoglobin leads to the export of vasodilator and antiadhesive S-nitrosothiols (SNOs) and adenosine triphosphate (ATP) in parallel with oxygen transport in the respiratory cycle. Together, these mediated responses to shear stress and oxygen offloading promote the efficient flow of blood cells and in turn optimize oxygen delivery. In diseases including sickle cell anemia and conditions including conventional blood banking, these adaptive functions may be compromised as a result, for example, of limited RBC deformability, impaired mediator formation, or dysfunctional mediator export. Ongoing work, including single cell approaches, is examining relevant mechanisms and remedies in health and disease.

Full Text

Duke Authors

Cited Authors

  • McMahon, TJ

Published Date

  • 2019

Published In

Volume / Issue

  • 10 /

Start / End Page

  • 1417 -

PubMed ID

  • 31803068

Pubmed Central ID

  • 31803068

International Standard Serial Number (ISSN)

  • 1664-042X

Digital Object Identifier (DOI)

  • 10.3389/fphys.2019.01417


  • eng

Conference Location

  • Switzerland