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Fluorescence spectroscopy for diagnosis of esophageal cancer

Publication ,  Conference
Panjehpour, M; Overholt, BF; Vo-Dinh, T; Farris, C; Schmidhammer, JL; Sneed, RE; Buckley, PF
Published in: Proceedings of SPIE - The International Society for Optical Engineering
July 19, 1994

Laser-induced fluorescence spectroscopy was employed to measure fluorescence emission of normal and malignant tissue during endoscopy in patients with esophageal adenocarcinoma. A nitrogen/dye laser tuned at 410 nm was used for excitation source. The fluorescence lineshape of each spectrum was determined and sampled at 15 nm intervals from 430 nm to 716 nm. A calibration set from normal and malignant spectra were selected. Using stepwise discriminate analysis, significant wavelengths that separated normal and malignant spectra were selected. The intensities at these wavelengths were used to formulate a classification model using linear discriminate analysis. The model was used to classify additional tissue spectra from 26 malignant and 108 normal sites into either normal or malignant spectra with a sensitivity of 100 percent and specificity of 98 percent.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

July 19, 1994

Volume

2133

Start / End Page

185 / 191

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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MLA
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Panjehpour, M., Overholt, B. F., Vo-Dinh, T., Farris, C., Schmidhammer, J. L., Sneed, R. E., & Buckley, P. F. (1994). Fluorescence spectroscopy for diagnosis of esophageal cancer. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2133, pp. 185–191). https://doi.org/10.1117/12.179982
Panjehpour, M., B. F. Overholt, T. Vo-Dinh, C. Farris, J. L. Schmidhammer, R. E. Sneed, and P. F. Buckley. “Fluorescence spectroscopy for diagnosis of esophageal cancer.” In Proceedings of SPIE - The International Society for Optical Engineering, 2133:185–91, 1994. https://doi.org/10.1117/12.179982.
Panjehpour M, Overholt BF, Vo-Dinh T, Farris C, Schmidhammer JL, Sneed RE, et al. Fluorescence spectroscopy for diagnosis of esophageal cancer. In: Proceedings of SPIE - The International Society for Optical Engineering. 1994. p. 185–91.
Panjehpour, M., et al. “Fluorescence spectroscopy for diagnosis of esophageal cancer.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 2133, 1994, pp. 185–91. Scopus, doi:10.1117/12.179982.
Panjehpour M, Overholt BF, Vo-Dinh T, Farris C, Schmidhammer JL, Sneed RE, Buckley PF. Fluorescence spectroscopy for diagnosis of esophageal cancer. Proceedings of SPIE - The International Society for Optical Engineering. 1994. p. 185–191.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

July 19, 1994

Volume

2133

Start / End Page

185 / 191

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering