Fluorescence spectroscopy for diagnosis of esophageal cancer


Conference Paper

© 1994 SPIE. All rights reserved. Laser-induced fluorescence spectroscopy was employed to measure fluorescence emission of normal and malignant tissue during endoscopy in patients with esophageal adenocarcinoma. A nitrogen/dye laser tuned at 410 nm was used for excitation source. The fluorescence lineshape of each spectrum was determined and sampled at 15 nm intervals from 430 nm to 716 nm. A calibration set from normal and malignant spectra were selected. Using stepwise discriminate analysis, significant wavelengths that separated normal and malignant spectra were selected. The intensities at these wavelengths were used to formulate a classification model using linear discriminate analysis. The model was used to classify additional tissue spectra from 26 malignant and 108 normal sites into either normal or malignant spectra with a sensitivity of 100 percent and specificity of 98 percent.

Full Text

Duke Authors

Cited Authors

  • Panjehpour, M; Overholt, BF; Vo-Dinh, T; Farris, C; Schmidhammer, JL; Sneed, RE; Buckley, PF

Published Date

  • July 19, 1994

Published In

Volume / Issue

  • 2133 /

Start / End Page

  • 185 - 191

Electronic International Standard Serial Number (EISSN)

  • 1996-756X

International Standard Serial Number (ISSN)

  • 0277-786X

Digital Object Identifier (DOI)

  • 10.1117/12.179982

Citation Source

  • Scopus