Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?

Journal Article (Journal Article)

The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a 'case study' to contrast the genetic landscape in natural populations with standard infection models, discussing new strategies to bridge this gap.

Full Text

Duke Authors

Cited Authors

  • Smith, CM; Sassetti, CM

Published Date

  • November 2018

Published In

Volume / Issue

  • 26 / 11

Start / End Page

  • 892 - 895

PubMed ID

  • 30166218

Pubmed Central ID

  • PMC6610874

Electronic International Standard Serial Number (EISSN)

  • 1878-4380

Digital Object Identifier (DOI)

  • 10.1016/j.tim.2018.08.002


  • eng

Conference Location

  • England