Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?
Publication
, Journal Article
Smith, CM; Sassetti, CM
Published in: Trends Microbiol
November 2018
The outcome of chronic infections is highly variable. The heterogeneous disease outcomes in natural populations differ from genetically homogeneous infection models. Here, we use tuberculosis as a 'case study' to contrast the genetic landscape in natural populations with standard infection models, discussing new strategies to bridge this gap.
Duke Scholars
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Published In
Trends Microbiol
DOI
EISSN
1878-4380
Publication Date
November 2018
Volume
26
Issue
11
Start / End Page
892 / 895
Location
England
Related Subject Headings
- Tuberculosis
- Mycobacterium tuberculosis
- Microbiology
- Mice, Inbred C57BL
- Mice
- Humans
- Host-Pathogen Interactions
- Genotype
- Genetic Variation
- Genetic Predisposition to Disease
Citation
APA
Chicago
ICMJE
MLA
NLM
Smith, C. M., & Sassetti, C. M. (2018). Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery? Trends Microbiol, 26(11), 892–895. https://doi.org/10.1016/j.tim.2018.08.002
Smith, Clare M., and Christopher M. Sassetti. “Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?” Trends Microbiol 26, no. 11 (November 2018): 892–95. https://doi.org/10.1016/j.tim.2018.08.002.
Smith CM, Sassetti CM. Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery? Trends Microbiol. 2018 Nov;26(11):892–5.
Smith, Clare M., and Christopher M. Sassetti. “Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery?” Trends Microbiol, vol. 26, no. 11, Nov. 2018, pp. 892–95. Pubmed, doi:10.1016/j.tim.2018.08.002.
Smith CM, Sassetti CM. Modeling Diversity: Do Homogeneous Laboratory Strains Limit Discovery? Trends Microbiol. 2018 Nov;26(11):892–895.
Published In
Trends Microbiol
DOI
EISSN
1878-4380
Publication Date
November 2018
Volume
26
Issue
11
Start / End Page
892 / 895
Location
England
Related Subject Headings
- Tuberculosis
- Mycobacterium tuberculosis
- Microbiology
- Mice, Inbred C57BL
- Mice
- Humans
- Host-Pathogen Interactions
- Genotype
- Genetic Variation
- Genetic Predisposition to Disease