Host resistance to malaria: using mouse models to explore the host response.

Journal Article (Journal Article;Review)

Malaria is a disease that infects over 500 million people, causing at least 1 million deaths every year, with the majority occurring in developing countries. The current antimalarial arsenal is becoming dulled due to the rapid rate of resistance of the parasite. However, in populations living in malaria-endemic regions there are many examples of genetic-based resistance to the severe effects of the parasite Plasmodium. Defining the genetic factors behind host resistance has been an area of great scientific interest over the last few decades; this review summarizes the current knowledge of the genetic loci involved. Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials.

Full Text

Duke Authors

Cited Authors

  • Longley, R; Smith, C; Fortin, A; Berghout, J; McMorran, B; Burgio, G; Foote, S; Gros, P

Published Date

  • February 2011

Published In

Volume / Issue

  • 22 / 1-2

Start / End Page

  • 32 - 42

PubMed ID

  • 21116636

Electronic International Standard Serial Number (EISSN)

  • 1432-1777

Digital Object Identifier (DOI)

  • 10.1007/s00335-010-9302-6


  • eng

Conference Location

  • United States