Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5.

Journal Article (Journal Article)

Background: Treatment planning for I-125 plaque therapy for uveal melanoma has advanced significantly since the Collaborative Ocular Melanoma Study trial, with more widely available image-guided planning and improved dosimetry. Objective: We evaluated real-world practice patterns for I-125 plaque brachytherapy in the United States by studying practice patterns at centers that comprise the Ocular Oncology Study Consortium (OOSC). Methods: The OOSC database and responses to a treatment practice survey were evaluated. The database contains treatment information from 9 institutions. Patients included in the database were treated between 2010 and 2014. The survey was conducted in 2018 and current treatment planning methods and prescriptions were queried. Results: Examination of the OOSC database revealed that average doses to critical structures were highly consistent, with the exception of one institution. Survey responses indicated that most centers followed published guidelines regarding dose and prescription point. Dose rate ranged from 51 to 118 cGy/h. As of 2018, most institutions use pre-loaded plaques and fundus photographs and/or computed tomography or magnetic resonance imaging in planning. Conclusions: While there were differences in dosimetric practices, overall agreement in plaque brachytherapy practices was high among OOSC institutions. Clinical margins and planning systems were similar among institutions, while prescription dose, dose rates, and dosimetry varied.

Full Text

Duke Authors

Cited Authors

  • Binder, C; Mruthyunjaya, P; Schefler, AC; Seider, MI; Crilly, R; Hung, A; Meltsner, S; Mowery, Y; Kirsch, DG; Teh, BS; Jennelle, RLS; Studenski, MT; Liu, W; Lee, C; Hayman, JA; Kastner, B; Hadsell, M; Skalet, AH

Published Date

  • May 2020

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 210 - 218

PubMed ID

  • 32509767

Pubmed Central ID

  • PMC7250354

International Standard Serial Number (ISSN)

  • 2296-4681

Digital Object Identifier (DOI)

  • 10.1159/000504312

Language

  • eng

Conference Location

  • Switzerland